Hepatitis Research Today is a free monthly online journal that collates and summarizes the latest research about Hepatitis, including details on hepatitis a, b, c, causes, symptoms.

Is the slippery slope from steatosis to steatohepatitis paved with triglyceride or cholesterol?

Ginsberg HN

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.

Accumulation of hepatic lipids has been thought to trigger the inflammation, apoptosis, and fibrosis that characterize progression of hepatic steatosis to steatohepatitis and cirrhosis. In this issue of Cell Metabolism, Marí et al. (2006) provide evidence for excessive mitochondrial free cholesterol as a cause of the progession of steatosis to more severe liver disease.

Published 4 September 2006 in Cell Metab, 4(3): 179-81.
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