Hepatitis Research Today is a free monthly online journal that collates and summarizes the latest research about Hepatitis, including details on hepatitis a, b, c, causes, symptoms.

Combination therapy for chronic hepatitis B: simultaneous or sequential?

Yuen MF, Lai CL

Various regimens of combination or sequential therapy using nucleoside/nucleotide analogues (NAs) and interferon-alfa (IFN-alpha) have been tried for the treatment of chronic hepatitis B. To date, combination therapy of two NAs and of IFN-alpha and NAs fails to achieve extra viral suppression. Sequential therapy with lamivudine followed by IFN-alpha seems to have better sustained virologic response. However, the long-term beneficial effect of using this approach remains to be defined.

Published 1 February 2007 in Am J Gastroenterol, 102(1): 105-6.
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