Hepatitis Research Today is a free monthly online journal that collates and summarizes the latest research about Hepatitis, including details on hepatitis a, b, c, causes, symptoms.

Performance characteristics of microparticle enzyme and chemiluminescence immunoassays for measurement of anti-HBc immunoglobulin M in sera of patients with HBeAg-negative chronic hepatitis B virus infection.

Hadziyannis E, Manesis E, Vassilopoulos D, Georgiou A, Archimandritis A

Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas. Sophias Ave., Athens 11527, Greece. emhadzi@med.uoa.gr

The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.

Published 4 February 2008 in Clin Vaccine Immunol, 15(2): 385-7.
Full-text of this article is available online (may require subscription).

© 2006-2008 Hepatitis Research Today. All Rights Reserved.